Medical College of Wisconsin
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Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis. J Pediatr 2007 Apr;150(4):358-63

Date

03/27/2007

Pubmed ID

17382110

DOI

10.1016/j.jpeds.2006.11.059

Scopus ID

2-s2.0-33947211314 (requires institutional sign-in at Scopus site)   56 Citations

Abstract

OBJECTIVE: To examine the ontogeny of salivary epidermal growth factor (sEGF) in premature infants and to determine the relation of sEGF to the development of necrotizing enterocolitis (NEC).

STUDY DESIGN: Salivary EGF was prospectively measured in 327 infants with gestational ages from 23 weeks to term. Infants of < or = 32 weeks' gestation (n = 261) were followed with weekly sEGF measurements through 3 weeks of life. Multivariable regression analyses were used to determine variables significantly related to sEGF levels and to identify predictors of NEC.

RESULTS: Over the first 3 weeks of life, sEGF increased across gestational age and postnatal age categories. In multivariable models, gestational age was a significant predictor of sEGF levels (P < .009). In a cohort of 27 infants who had NEC, gestational age, race, and changes in sEGF levels between weeks of life 1 and 2 were predictive of the development of NEC. These infants had lower sEGF at week 1 and greater increases from week 1 to week 2 compared with infants without NEC.

CONCLUSIONS: There is a positive relation between sEGF levels and gestational age. Patterns of sEGF levels over the first 2 weeks of life were significantly related to development of NEC in very low birth weight infants.

Author List

Warner BB, Ryan AL, Seeger K, Leonard AC, Erwin CR, Warner BW

Author

Kimberly Seeger MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Age Factors
Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Apgar Score
Cohort Studies
Enterocolitis, Necrotizing
Epidermal Growth Factor
Female
Gestational Age
Humans
Indomethacin
Infant Formula
Infant, Newborn
Infant, Premature
Male
Milk, Human
Multivariate Analysis
Odds Ratio
Ohio
Prospective Studies
Regression Analysis
Risk Factors
Saliva