Rat genetics: attaching physiology and pharmacology to the genome. Nat Rev Genet 2002 Jan;3(1):33-42
Date
02/02/2002Pubmed ID
11823789DOI
10.1038/nrg702Scopus ID
2-s2.0-0036250938 (requires institutional sign-in at Scopus site) 223 CitationsAbstract
During the past five years, the Rat Genome Project has been rapidly gaining momentum, especially since the announcement in August 2000 of plans to sequence the rat genome. Combined with the wealth of physiological and pharmacological data for the rat, the genome sequence should facilitate the discovery of mammalian genes that underlie the physiological pathways that are involved in disease. Most importantly, this combined physiological and genomic information should also lead to the development of better pre-clinical models of human disease, which will aid in the development of new therapeutics.
Author List
Jacob HJ, Kwitek AEAuthor
Anne E. Kwitek PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDisease Models, Animal
Genome
Humans
Pharmacology
Physiology
Quantitative Trait, Heritable
Rats