Translational study of microRNAs and its application in kidney disease and hypertension research. Clin Sci (Lond) 2012 May 01;122(10):439-47
Date
01/31/2012Pubmed ID
22283365Pubmed Central ID
PMC4428581DOI
10.1042/CS20110159Scopus ID
2-s2.0-84858729145 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
MicroRNA research in humans and mammalian model organisms is in a crucial stage of development. Diagnostic and therapeutic values of microRNAs appear promising, but remain to be established. The physiological and pathophysiological significance of microRNAs is generally recognized, but much better understood in some organ systems and disease areas than others. In the present paper, we review several translational studies of microRNAs, including those showing the potential value of therapeutic agents targeting microRNAs and diagnostic or prognostic microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges, but provides many opportunities to develop and apply new methods, and to merge complementary basic and clinical approaches.
Author List
Kriegel AJ, Mladinov D, Liang MAuthor
Alison J. Kriegel PhD Associate Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiomarkers
Gene Expression Regulation
Humans
Hypertension
Kidney Diseases
Mice
MicroRNAs