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Translational study of microRNAs and its application in kidney disease and hypertension research. Clin Sci (Lond) 2012 May 01;122(10):439-47

Date

01/31/2012

Pubmed ID

22283365

Pubmed Central ID

PMC4428581

DOI

10.1042/CS20110159

Scopus ID

2-s2.0-84858729145   15 Citations

Abstract

MicroRNA research in humans and mammalian model organisms is in a crucial stage of development. Diagnostic and therapeutic values of microRNAs appear promising, but remain to be established. The physiological and pathophysiological significance of microRNAs is generally recognized, but much better understood in some organ systems and disease areas than others. In the present paper, we review several translational studies of microRNAs, including those showing the potential value of therapeutic agents targeting microRNAs and diagnostic or prognostic microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges, but provides many opportunities to develop and apply new methods, and to merge complementary basic and clinical approaches.

Author List

Kriegel AJ, Mladinov D, Liang M

Authors

Alison J. Kriegel PhD Associate Professor in the Physiology department at Medical College of Wisconsin
Mingyu Liang PhD Center Director, Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Biomarkers
Gene Expression Regulation
Humans
Hypertension
Kidney Diseases
Mice
MicroRNAs
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