A Case of Amyloid Light-Chain Amyloidosis Presenting as Colitis. Cureus 2026 Feb;18(2):e103605
Date
03/18/2026Pubmed ID
41846637Pubmed Central ID
PMC12991382DOI
10.7759/cureus.103605Abstract
Gastrointestinal amyloidosis is a rare but often a manifestation of an advanced form of systemic amyloidosis that carries a poor prognosis. Its presentation may mimic ischemic bowel disease, inflammatory bowel disease, celiac disease, or protein-losing enteropathy, among others. Often, varied presentations make it difficult to diagnose. Hence, a careful and systematic approach with an aggressive treatment strategy is needed for prompt diagnosis and treatment of the fatal condition. Here, we report a fatal case of systemic amyloidosis (amyloid light-chain (AL) amyloidosis) with its initial presentation including gastrointestinal symptoms and subsequent rapid clinical deterioration due to worsening renal function and evidence of pericardial effusion.
Author List
Prabakaran K, Khan S, Mei L, Edeani F, Sanvanson P, Sivasubramaniam P, Ali M, Balasubramanian GAuthors
Francis Edeani MBBS Associate Professor in the Medicine department at Medical College of WisconsinPatrick P. Sanvanson MD Associate Professor in the Medicine department at Medical College of Wisconsin
