Recent progress and future directions to advance glioblastoma research: A consensus perspective from the 2024 Christopher Davidson Forum. Neuro Oncol 2026 Jun 01;28(6):1366-1382
Date
03/24/2026Pubmed ID
41871616DOI
10.1093/neuonc/noag043Scopus ID
2-s2.0-105041052699 (requires institutional sign-in at Scopus site)Abstract
This position paper from the 2024 Christopher Davidson Forum held at WashU Medicine in Saint Louis provides a comprehensive consensus on scientific advances, key challenges, and future directions in glioblastoma (GBM) research. A multidisciplinary group of over 130 academic neuro-oncology professionals discussed recent developments and existing gaps in understanding the complex tumor biology of GBM tumors, characterizing and overcoming the resistance of GBM to immunotherapeutic approaches, defining tumor-brain interactions and their functional consequences for tumor progression and therapy resistance, and developing and clinically translating novel neuro- and nanotechnologies. We conclude with a call to action for researchers and clinicians in the neuro-oncology field to address fundamental gaps in our understanding of GBM tumor, immune, and neurobiology, and develop critical infrastructure to more rapidly translate novel therapeutic paradigms into the clinic through multi-disciplinary and cross-institutional collaborations.
Author List
Dunn GP, Yu KKH, Krucoff MO, Bojanowski-Hoang K, Goldschmidt E, Erol-Demirturk M, Adesina D, Quintana D, Winkler F, Hervey-Jumper S, Deneen B, Giles DA, Ko CH, Leuthardt EC, Kim AH, Stegh AH, Christopher Davidson Forum InvestigatorsAuthor
Max O. Krucoff BS, MD Associate Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiomedical Research
Brain Neoplasms
Glioblastoma
Humans
