Postmenopausal hormone therapy and its association with cognitive impairment. Arch Intern Med 2003 Nov 10;163(20):2485-90
Date
11/12/2003Pubmed ID
14609785DOI
10.1001/archinte.163.20.2485Scopus ID
2-s2.0-0242424183 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
BACKGROUND: Cognitive impairment is a common and potentially debilitating medical problem in older women. Postmenopausal hormone therapy (HT) has been associated with better cognitive function, but the literature is conflicting. Results of recent trials suggest that HT is inappropriate for prevention of heart disease, and we sought to determine the role of HT in the risk of cognitive impairment.
METHODS: We measured HT use and cognitive function in a population-based cohort of 1462 postmenopausal women participating in the 5-year follow-up examination for the Epidemiology of Hearing Loss Study in 1998-2000. The cohort was defined in 1987-1988 by residency in Beaver Dam, Wis, and an age of 43 to 84 years. Women had also participated in the Beaver Dam Eye Study baseline examination in 1988-1990. Use of HT was assessed at the Beaver Dam Eye Study baseline (1988-1990), 5-year follow-up (1993-1995), and 10-year follow-up (1998-2000) visits. Cognitive impairment was defined as a low Mini-Mental State Examination score or a reported diagnosis of Alzheimer disease.
RESULTS: Six percent of participants (n = 94) were impaired; these women were significantly older and less educated than those who were unimpaired. In age- and education-adjusted analysis, current HT use was not significantly associated with cognitive impairment (odds ratio, 0.6; 95% confidence interval, 0.2-1.3). Similarly, cognitive impairment was not associated with past HT use or duration of HT use.
CONCLUSION: In this large population-based study, postmenopausal hormone therapy was not significantly associated with better cognitive function.
Author List
Mitchell JL, Cruickshanks KJ, Klein BE, Palta M, Nondahl DMAuthor
Julie L. Mitchell MD Adjunct Professor in the Family Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAge Factors
Aged
Aged, 80 and over
Cognition
Cognition Disorders
Cohort Studies
Estrogen Replacement Therapy
Estrone
Female
Humans
Middle Aged
Treatment Outcome
Wisconsin