Accuracy and precision of intraocular injection volume. Am J Ophthalmol 2002 Apr;133(4):564-6
Date
04/05/2002Pubmed ID
11931796DOI
10.1016/s0002-9394(01)01408-8Scopus ID
2-s2.0-0036207045 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
PURPOSE: To assess the accuracy and precision of methods in clinical use for intraocular drug injection.
DESIGN: Experimental laboratory investigation.
METHODS: A total of 800 injections were performed using 20 different 1-ml syringes at intended volumes of 0.10 ml and 0.05 ml. The volume of each injection was calculated from mass of water delivered onto an analytic balance.
RESULTS: The mean measured volume delivered was less than the intended volume for every syringe (P <.001 for each syringe at each volume). A total of 7% and 22% of injections differed by 20% or more from the intended volumes of 0.10 ml and 0.05 ml, respectively. Overdelivery of volume was uncommon.
CONCLUSION: Clinically relevant materials and methods used for intraocular injection of drugs systematically underdelivered the intended volume.
Author List
Raju JR, Weinberg DVAuthor
David V. Weinberg MD Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
InjectionsOphthalmology
Reference Standards
Reproducibility of Results
Syringes
Weights and Measures