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Clinical applications of cardiovascular angiogenesis. J Card Surg 2001 Nov-Dec;16(6):490-7



Pubmed ID




Scopus ID

2-s2.0-0035573438   8 Citations


Angiogenesis is fundamental to both normal physiologic (wound healing) and pathologic (cancer) processes. Manipulation of divergent angiogenic signals promises effective therapy of atherosclerotic cardiovascular disease. Positive proangiogenic strategies promise collateral circulation to ischemic territories, while negative antiangiogenic strategies starve the fibromuscular proliferation within the atherosclerotic lesion. Indeed, recent phase 1 trials suggest that delivering DNA or recombinant protein to the site of vascular occlusion may stimulate physiologically significant collateral circulation in chronically ischemic myocardium. While symptomatic and functional improvement has been documented, toxicity profiles and effects on long-term patient survival are still unclear. The purposes of this article are as follows: (1) to review the pathophysiologic basis for pro- and antiangiogenic strategies in the treatment of cardiovascular disease, (2) to examine the clinical trials of proangiogenic gene or recombinant protein delivery into ischemic beds, and conversely, (3) to explore antiangiogenic strategies in the prevention and treatment of intimal neovascularization and smooth muscle proliferation within the vessel wall.

Author List

Zimmerman MA, Selzman CH, Raeburn CD, Calkins CM, Barsness K, Harken AH


Casey Matthew Calkins MD Professor in the Surgery department at Medical College of Wisconsin
Michael A. Zimmerman MD, FACS Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cardiovascular System
Clinical Trials as Topic
Coronary Artery Disease
Endothelial Growth Factors
Neovascularization, Pathologic
Neovascularization, Physiologic
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0