Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence. Drug Alcohol Depend 2017 Nov 01;180:234-240
Date
09/22/2017Pubmed ID
28934666Pubmed Central ID
PMC5754220DOI
10.1016/j.drugalcdep.2017.08.024Scopus ID
2-s2.0-85031710117 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
Behavioral approach, defined as behavior directed toward a reward or novel stimulus, when elevated, may increase one's vulnerability to substance use disorder. Behavioral approach has been associated with relatively greater left compared to right frontal activity; behavioral inhibition may be associated with relatively greater right compared to left frontal brain activity. We hypothesized that substance dependent individuals (SDI) would have higher behavioral approach than controls and greater prefrontal cortical activity during decision-making involving reward. We hypothesized that behavioral approach would correlate with left frontal activity during decision-making and that the correlation would be stronger in SDI than controls. 31 SDI and 21 controls completed the Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scales and performed a decision-making task during fMRI. Orbitofrontal (OFC) and dorsolateral prefrontal activity were correlated with BIS and BAS scores. Compared to controls, SDI had higher BAS Fun Seeking scores (p<0.001) and worse decision-making performance (p=0.004). BAS Fun Seeking correlated with left OFC activity during decision-making across group (r=0.444, p<0.003). The correlation did not differ by group. There was no correlation between BIS and right frontal activity. Left OFC may play a role in reward-related decision-making in substance use disorder especially in individuals with high behavioral approach.
Author List
Yamamoto DJ, Banich MT, Regner MF, Sakai JT, Tanabe JAuthor
Michael Regner MD Associate Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Decision MakingHumans
Magnetic Resonance Imaging
Prefrontal Cortex
Reward
Substance-Related Disorders
