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IQGAP1: a regulator of intracellular spacetime relativity. J Immunol 2012 Mar 01;188(5):2057-63

Date

02/22/2012

Pubmed ID

22345702

Pubmed Central ID

PMC3286039

DOI

10.4049/jimmunol.1102439

Scopus ID

2-s2.0-84857476097 (requires institutional sign-in at Scopus site)   39 Citations

Abstract

Activating and inhibiting receptors of lymphocytes collect valuable information about their mikròs kósmos. This information is essential to initiate or to turn off complex signaling pathways. Irrespective of these advances, our knowledge on how these intracellular activation cascades are coordinated in a spatiotemporal manner is far from complete. Among multiple explanations, the scaffolding proteins have emerged as a critical piece of this evolutionary tangram. Among many, IQGAP1 is one of the essential scaffolding proteins that coordinate multiple signaling pathways. IQGAP1 possesses multiple protein interaction motifs to achieve its scaffolding functions. Using these domains, IQGAP1 has been shown to regulate a number of essential cellular events. This includes actin polymerization, tubulin multimerization, microtubule organizing center formation, calcium/calmodulin signaling, Pak/Raf/Mek1/2-mediated Erk1/2 activation, formation of maestrosome, E-cadherin, and CD44-mediated signaling and glycogen synthase kinase-3/adenomatous polyposis coli-mediated β-catenin activation. In this review, we summarize the recent developments and exciting new findings of cellular functions of IQGAP1.

Author List

Malarkannan S, Awasthi A, Rajasekaran K, Kumar P, Schuldt KM, Bartoszek A, Manoharan N, Goldner NK, Umhoefer CM, Thakar MS

Authors

Subramaniam Malarkannan PhD Professor in the Medicine department at Medical College of Wisconsin
Allison Reeme in the CTSI department at Medical College of Wisconsin - CTSI




MESH terms used to index this publication - Major topics in bold

Animals
Cell Communication
Cells, Cultured
Intracellular Space
Lymphocyte Subsets
Mice
Mice, Knockout
Protein Interaction Mapping
Protein Multimerization
Signal Transduction
ras GTPase-Activating Proteins