Dynamic activity of Erg promotes maturation of the hematopoietic system. Blood Adv 2026 Feb 10;10(3):759-773
Date
11/05/2025Pubmed ID
41191516Pubmed Central ID
PMC12874306DOI
10.1182/bloodadvances.2025017705Scopus ID
2-s2.0-105029746489 (requires institutional sign-in at Scopus site)Abstract
Hematopoiesis changes over the lifetime to adapt to the physiology of development, maturation, and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of certain blood diseases. Several heterochronic regulators of hematopoiesis have been identified, but how the master transcription factor (TF) circuitry of definitive hematopoietic stem cells (HSCs) adapts to changes in physiology over the life span remains unknown. In this study, we show that programmed upregulation of expression of the erythroblast transformation-specific family TF Erg from prenatal to adult maturation is evolutionarily conserved and required for implementation of adult patterns of HSC self-renewal and myeloid, erythroid, and lymphoid differentiation. Erg deficiency maintains fetal transcriptional and epigenetic programs in adulthood, and persistent juvenile phenotypes in Erg haploinsufficient mice are at least in part dependent on deregulation of the fetal-biased factor Hmga2. Overall, we identify a mechanism whereby master HSC TF networks are rewired to specify stage-specific hematopoiesis, a finding directly relevant to age-biased blood diseases.
Author List
Tanaka-Yano M, Sugden WW, Wang D, Falchetti M, Badalamenti B, Côté P, Chin D, Goldstein J, George S, Rodrigues-Luiz GF, Lummertz da Rocha E, Li H, North TE, Gryder BE, Rowe RGAuthor
Wade W. Sugden PhD Assistant Professor in the Cell Biology Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Differentiation
Hematopoiesis
Hematopoietic Stem Cells
Hematopoietic System
Humans
Mice
Oncogene Proteins
Transcriptional Regulator ERG
