Updates in Antiphospholipid Syndrome Laboratory Diagnosis. Clin Lab Med 2026 Jun;46(2):295-311
Date
05/16/2026Pubmed ID
42140686DOI
10.1016/j.cll.2026.02.006Scopus ID
2-s2.0-105034697059 (requires institutional sign-in at Scopus site)Abstract
Dramatic improvements have been made in antiphospholipid syndrome (APS) diagnosis, but work is still needed around standardization of laboratory practice and lupus anticoagulant (LA) testing with anticoagulated samples. LA testing in anticoagulated patients is common, and can lead to false positivity and possibly false negativity. For patients whose anticoagulation cannot be held, LA testing accuracy can be improved by activated carbon pre-treatment or alternative LA reagents. Solid phase testing for antiphospholipid antibodies remains incompletely harmonized and recent International Society on Thrombosis and Haemostasis (ISTH) and American College of Rheumatology (ACR)/ European League against Rheumatism (EULAR) guidelines do not completely agree.
Author List
Wool GDAuthor
Geoffrey D. Wool MD, PhD Professor in the Pathology and Laboratory Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Antibodies, AntiphospholipidAnticoagulants
Antiphospholipid Syndrome
Clinical Laboratory Techniques
Humans
Lupus Coagulation Inhibitor
