Umbilical Amniotic Tissue Graft as an Alternative Approach for Eyelid Reconstruction After Necrotizing Fasciitis Debridement. Ophthalmic Plast Reconstr Surg 2025 Jan-Feb 01;41(1):e18-e22
Date
12/26/2024Pubmed ID
39724647DOI
10.1097/IOP.0000000000002793Scopus ID
2-s2.0-85206909159 (requires institutional sign-in at Scopus site)Abstract
A 54-year-old female with myelodysplastic syndrome on chemotherapy presented with 10 days of periocular erythema and edema worsening on oral antibiotics. Computed Tomography scan showed periorbital soft tissue swelling without postseptal extension or abscess. Intravenous broad-spectrum antibiotics were administered. However, she developed necrosis of the upper eyelid requiring aggressive debridement. Nine days after debridement, the defect measuring 5.5 × 3 cm was covered using an umbilical amniotic tissue graft (AmnioGuard, BioTissue, Miami, FL). At postoperative week 4, 5-fluorouracil was injected to prevent the shortening of anterior lamella. At postoperative week 20, the graft had dissolved and been replaced by regenerated skin. Final eyelid exam demonstrated normal eyelid elevation and minimal lagophthalmos. Herein, we present a case of umbilical amniotic membrane as a substrate graft to support the healing of the eyelid defect by secondary intention.
Author List
Mirzania D, Zhao Z, Kim DS, Aakalu VK, Nelson CCAuthor
Vinay Kumar Aakalu MPH, MD Chair, Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AmnionBlepharoplasty
Debridement
Eyelid Diseases
Eyelids
Fasciitis, Necrotizing
Female
Humans
Middle Aged
Umbilicus
