Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes. Ocul Surf 2021 Apr;20:163-172
Date
03/02/2021Pubmed ID
33647470Pubmed Central ID
PMC8113161DOI
10.1016/j.jtos.2021.02.010Scopus ID
2-s2.0-85101785327 (requires institutional sign-in at Scopus site) 37 CitationsAbstract
Neurotrophic keratopathy is a degenerative disease in which damage to the corneal nerves leads to corneal hypoesthesia. Injuries to neurotrophic corneas are notoriously difficult to treat and have traditionally been approached with supportive management. However, recent progress in the field of corneal neurotization has given new direction for addressing nerve loss directly by stimulating new nerve growth onto the cornea from nearby sensory nerves transferred to the perilimbal region. Herein, we review the surgical techniques utilized in corneal neurotization, including direct transfers and the use of nerve grafts. Considerations in surgical approach, as well as factors that influence prognosis and outcomes of the surgical intervention are also discussed.
Author List
Liu CY, Arteaga AC, Fung SE, Cortina MS, Leyngold IM, Aakalu VKAuthor
Vinay Kumar Aakalu MPH, MD Chair, Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
CorneaCorneal Diseases
Corneal Dystrophies, Hereditary
Humans
Nerve Regeneration
Nerve Transfer
Trigeminal Nerve Diseases
