The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases. Int J Mol Sci 2021 Jan 13;22(2)
Date
01/17/2021Pubmed ID
33450870Pubmed Central ID
PMC7828360DOI
10.3390/ijms22020721Scopus ID
2-s2.0-85099396825 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus on antimicrobial peptides and the role they play in the immune response of the ocular surface during healthy states and dry eye diseases. Antimicrobial peptides are of special interest to the study of the ocular surface because of their various roles that include microbial threat neutralization, wound healing, and immune modulation. This review explores current literature on antimicrobial peptides in ocular surface diseases and discusses their therapeutic potential in ocular surface diseases and dry eye.
Author List
Eshac Y, Redfern RL, Aakalu VKAuthor
Vinay Kumar Aakalu MPH, MD Chair, Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiomarkers
Biosynthetic Pathways
Cornea
Defensins
Disease Management
Disease Susceptibility
Dry Eye Syndromes
Gene Expression
Humans
Immunity, Innate
Immunomodulation
Pore Forming Cytotoxic Proteins
Protein Transport
Toll-Like Receptors
