Wound Healing Properties of Histatin-5 and Identification of a Functional Domain Required for Histatin-5-Induced Cell Migration. Mol Ther Methods Clin Dev 2020 Jun 12;17:709-716
Date
04/30/2020Pubmed ID
32346548Pubmed Central ID
PMC7178547DOI
10.1016/j.omtm.2020.03.027Scopus ID
2-s2.0-85083299085 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
Histatin peptides are endogenous anti-microbial peptides that were originally discovered in the saliva. Aside from their broad anti-microbial properties, these peptides play an important role in multiple biological systems. Different members of this family are thought to have relative specializations, with histatin-5 originally being thought to have mostly anti-fungal properties, and histatin-1 having strong wound healing properties. In this report, we describe the robust wound healing properties of histatin-5 and elucidate a functional domain, which is necessary and sufficient for promoting wound healing. We demonstrate these findings in multiple different cell types in vitro and with a standardized murine corneal wound healing model. Discovery of this wound healing domain and description of this functional role of histatin-5 will support developing therapies.
