Medical College of Wisconsin
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Hepatitis C status and infectious complications in the surgical intensive care unit: a retrospective analysis of 1,941 consecutive patients. Am J Surg 2016 Jun;211(6):1064-70

Date

01/10/2016

Pubmed ID

26746567

DOI

10.1016/j.amjsurg.2015.07.033

Scopus ID

2-s2.0-84960910809 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

BACKGROUND: Hepatitis C virus (HCV) infection is thought to be associated with immune dysfunction. We hypothesized that HCV status would be associated with increased infectious complications in the surgical intensive care unit (SICU).

METHODS: All patients admitted to our SICU between 2008 and 2012 were included. We evaluated 90-day mortality and infectious complications in the SICU. Multivariate logistic regression was performed to identify predictors of infectious complications and 90-day mortality.

RESULTS: A total of 1,941 patients were included. The HCV-positive group had a higher overall incidence of infectious complications (25% vs 18%), particularly ventilator-associated pneumonia (VAP) and bacteremia. The increased incidences of VAP and bacteremia persisted when cirrhotic patients were excluded. Prolonged intubation (Odds Ratio [OR] = 2.1), abdominal surgery (OR = 1.6), and model for end-stage liver disease ≥ 15 (OR = 1.4) were independent predictors of SICU infectious complications.

CONCLUSIONS: The HCV-positive group had an increased incidence of infectious complications in the SICU, particularly VAP and bacteremia. This effect persisted when cirrhotic patients were excluded.

Author List

Kueht M, Bebko S, Helmick R, Awad S

Author

Ryan Helmick MD Associate Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Bacteremia
Cause of Death
Critical Care
Cross Infection
Databases, Factual
Female
Follow-Up Studies
Hepatitis C, Chronic
Hospital Mortality
Humans
Immunocompromised Host
Intensive Care Units
Logistic Models
Male
Middle Aged
Multivariate Analysis
Postoperative Complications
Retrospective Studies
Risk Assessment
Survival Rate
United States