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Is There a Role for Desmopressin in Liver Transplantation? A Case Report. Transplant Proc 2015 Nov;47(9):2782-5

Date

12/19/2015

Pubmed ID

26680094

DOI

10.1016/j.transproceed.2015.09.044

Scopus ID

2-s2.0-84949514181 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Living donor liver transplantation reduces time and mortality on the waiting list. Bleeding is a serious complication; however, "overcorrection" of coagulopathy may lead to hepatic artery thrombosis. We report a case where desmopressin (DDAVP) was used in the management of persistent postreperfusion bleeding (44 red blood cell units transfused). After 1 dose of DDAVP, bleeding improved significantly and the recipient had an unremarkable recovery. DDAVP should be considered for persisting bleeding after correcting common coagulation abnormalities where complexity of the anastomosis may preclude the use of more aggressive procoagulant drugs in liver transplantation.

Author List

Gonzales MM, Valdes DZ, Helmick R, Taner T, Vasdev G

Author

Ryan Helmick MD Associate Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Deamino Arginine Vasopressin
Hemostatics
Humans
Liver
Liver Transplantation
Male
Middle Aged
Postoperative Hemorrhage
Reperfusion Injury