Epithelial regulation of microbiota-immune cell dynamics. Mucosal Immunol 2024 Apr;17(2):303-313
Date
03/02/2024Pubmed ID
38428738Pubmed Central ID
PMC11412483DOI
10.1016/j.mucimm.2024.02.008Scopus ID
2-s2.0-85187354253 (requires institutional sign-in at Scopus site) 39 CitationsAbstract
The mammalian gastrointestinal tract hosts a diverse community of trillions of microorganisms, collectively termed the microbiota, which play a fundamental role in regulating tissue physiology and immunity. Recent studies have sought to dissect the cellular and molecular mechanisms mediating communication between the microbiota and host immune system. Epithelial cells line the intestine and form an initial barrier separating the microbiota from underlying immune cells, and disruption of epithelial function has been associated with various conditions ranging from infection to inflammatory bowel diseases and cancer. From several studies, it is now clear that epithelial cells integrate signals from commensal microbes. Importantly, these non-hematopoietic cells also direct regulatory mechanisms that instruct the recruitment and function of microbiota-sensitive immune cells. In this review, we discuss the central role that has emerged for epithelial cells in orchestrating intestinal immunity and highlight epithelial pathways through which the microbiota can calibrate tissue-intrinsic immune responses.
Author List
Didriksen BJ, Eshleman EM, Alenghat TAuthor
Emily M. Eshleman PhD Assistant Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsHumans
Immune System
Inflammatory Bowel Diseases
Intestinal Mucosa
Intestines
Mammals
Microbiota
