Faculty Collaboration Database

Use of polylactide resorbable film as an adhesion barrier. J Neurosurg 2002 Nov;97(4 Suppl):413-22

Date

11/27/2002

Pubmed ID

12449195

DOI

10.3171/spi.2002.97.4.0413

Scopus ID

2-s2.0-0036828929 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

OBJECT: The present investigation evaluates two thicknesses of a resorbable polylactic acid (PLA) barrier film as an adhesion barrier to posterior spinal scar formation.

METHODS: A readily contourable, thin film was placed directly over the dura. The thick film was placed above the lamina defect to act as a physical barrier inhibiting the prolapse of soft tissue into the epidural space. Through a combination of gross dissection with and without scar scores, quantitative analysis of collagen adjacent to the scar site, and histological evaluation, the resorbable adhesion barrier membranes were found to be effective treatment for reduction of posterior adhesions.

CONCLUSIONS: The gross dissection demonstrated that both thicknesses of resorbable PLA barrier films created a controlled dissection plane, facilitated access to the epidural space, and provided a reduction in the tissue adherent to the dura.

Author List

Welch WC, Thomas KA, Cornwall GB, Gerszten PC, Toth JM, Nemoto EM, Turner AS

Author

Jeffrey M. Toth PhD Associate Dean for Research in the School of Dentistry department at Marquette University

MESH terms used to index this publication - Major topics in bold

Absorbable Implants
Animals
Basement Membrane
Biocompatible Materials
Cicatrix
Disease Models, Animal
Dogs
Dura Mater
Laminectomy
Polyesters
Postoperative Complications
Sheep
Tissue Adhesions