Faculty Collaboration Database

Number of sinus procedures reduces inpatient mortality for invasive fungal rhinosinusitis. Am J Otolaryngol 2024;45(5):104392

Date

07/26/2024

Pubmed ID

39047622

DOI

10.1016/j.amjoto.2024.104392

Scopus ID

2-s2.0-85199263658 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

OBJECTIVES: To evaluate surgical outcomes of invasive fungal rhinosinusitis MATERIALS AND METHODS: The National Inpatient Sample Database (2000-2015 Q3) was queried for patients with a diagnosis of aspergillosis and/or mucormycosis and a diagnosis of acute sinusitis using the International Classification of Diseases, Ninth Edition. Factors associated with inpatient mortality were then identified with multivariate logistic regression.

RESULTS: 514 adult patients with a median age of 57.0 years were identified, of which 231 (44.9 %) underwent sinus surgery. Surgical patients had a longer length of stay (17.0 vs 9.0 days, p < 0.001) and higher total charges ($139,762.00 vs $57,945.00, p < 0.001). The number of sinus procedures was associated with reduced odds of inpatient mortality (OR 0.69; p < 0.001) in multivariate analysis. Hypertension (OR 0.34, p = 0.002) and chronic kidney disease (OR 0.23, p = 0.034) were associated with reduced odds of inpatient mortality. Total number of procedures (OR 1.24; p = 0.002), mucormycosis (OR 2.75, p = 0.002), age (OR 1.03, p = 0.006) and acid-base disorders (OR 2.85, p = 0.012) were associated with increased odds of inpatient mortality.

CONCLUSION: This represents the first large scale study to evaluate outcomes for invasive fungal rhinosinusitis. These findings suggest the odds of inpatient mortality decrease with greater extent of sinus surgery performed. The potentially protective roles of hypertension and chronic kidney disease should be evaluated in future research.

Author List

Qu RW, Feng M, Stanyer B, Lee SC

Author

Max Feng MD Instructor in the Otolaryngology and Communication Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Aspergillosis
Female
Hospital Mortality
Humans
Hypertension
Invasive Fungal Infections
Length of Stay
Male
Middle Aged
Mucormycosis
Renal Insufficiency, Chronic
Treatment Outcome