Epstein-Barr Virus Versus Novel Coronavirus-Induced Hemophagocytic Lymphohistocytosis: The Uncharted Waters. J Investig Med High Impact Case Rep 2020;8:2324709620950107
Date
08/14/2020Pubmed ID
32787459Pubmed Central ID
PMC7427003DOI
10.1177/2324709620950107Scopus ID
2-s2.0-85089410606 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome characterized by fever, hepatosplenomegaly, and pancytopenia. It may be associated with genetic mutations or viral/bacterial infections, most commonly Epstein-Barr virus (EBV) and cytomegalovirus. As for the novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as COVID-19 (coronavirus disease-2019), the cytokine storm it triggers can theoretically lead to syndromes similar to HLH. In this article, we report a case of a 28-year-old female who presented with high-grade fevers, found to have both SARS-CoV-2 and EBV infections, and eventually began to show signs of early HLH. To our knowledge, this is the first case reported in literature that raises the possibility of SARS-CoV-2-related HLH development.
Author List
Amir R, Kichloo A, Singh J, Bhanot R, Aljadah M, Kumar A, Albosta MS, Solanki SAuthor
Michael M. Aljadah MD Instructor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBetacoronavirus
Coronavirus Infections
Epstein-Barr Virus Infections
Female
Herpesvirus 4, Human
Humans
Lymphohistiocytosis, Hemophagocytic
Pandemics
Pneumonia, Viral
