Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis. Mol Carcinog 2013 Sep;52(9):686-91
Date
03/30/2012Pubmed ID
22456940DOI
10.1002/mc.21907Scopus ID
2-s2.0-84881612712 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
Betanin, also called beetroot red, has been extensively used as a food colorant. In this study, the chemopreventive activity of betanin by oral consumption was investigated in two mouse lung tumor models. Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) were used to induce lung tumors, and female A/J mice were treated with betanin in drinking water. Betanin significantly decreased tumor multiplicity and tumor load induced by both carcinogens. Tumor multiplicity and tumor load were decreased by 20% and 39% in the VC lung model, and by 46% and 65% in the B(a)P lung model, respectively. Betanin reduced the number of CD31+ endothelial microvessels and increased the expression of caspase-3, suggesting that the lung tumor inhibitory effects were through induction of apoptosis and inhibition of angiogenesis. Betanin also induced apoptosis through activated caspase-3, -7, -9, and PARP in human lung cancer cell lines. Our data show that betanin significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer.
Author List
Zhang Q, Pan J, Wang Y, Lubet R, You MMESH terms used to index this publication - Major topics in bold
AnimalsAnticarcinogenic Agents
Apoptosis
Benzo(a)pyrene
Betacyanins
Caspases
Cell Transformation, Neoplastic
Endothelium, Vascular
Female
Lung Neoplasms
Mice
Mice, Inbred A
Neovascularization, Pathologic
Platelet Endothelial Cell Adhesion Molecule-1
Poly(ADP-ribose) Polymerases
Random Allocation
Urethane