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Antidepressant use, depressive symptoms, and incident frailty in women aged 65 and older from the Women's Health Initiative Observational Study. J Am Geriatr Soc 2012 May;60(5):854-61

Date

05/10/2012

Pubmed ID

22568404

Pubmed Central ID

PMC3354009

DOI

10.1111/j.1532-5415.2012.03940.x

Scopus ID

2-s2.0-84861231536   92 Citations

Abstract

OBJECTIVES: To examine the associations between depressive symptoms, antidepressant use, and duration of use with incident frailty 3 years later in nonfrail women aged 65 and older.

DESIGN: Secondary analysis of the Women's Health Initiative Observational Study (WHI-OS), a prospective cohort study.

SETTING: WHI-OS was conducted in 40 U.S. clinical centers.

PARTICIPANTS: Women aged 65 to 79, not frail at baseline.

MEASUREMENTS: Antidepressant use was assessed through medication container inspection at baseline. Four groups were created according to baseline use and Burnam depression screen (range 0-1, 0.06 cutoff): antidepressant nonusers without depressive symptoms (reference group), antidepressant nonusers with depressive symptoms, antidepressant users without depressive symptoms, and antidepressant users with depressive symptoms. Frailty components included slowness or weakness, exhaustion, low physical activity, and unintended weight loss, ascertained through self-report and physical measurements at baseline and Year 3.

RESULTS: Of 27,652 women at baseline, 1,350 (4.9%) were antidepressant users and 1,794 (6.5%) were categorized as depressed. At Year 3, 4,125 (14.9%) were frail. All groups had a greater risk of incident frailty than the reference group. Odds ratios (ORs) ranged from 1.73 (95% confidence interval (CI) = 1.41-2.12) in antidepressant users who were not depressed to 3.63 in antidepressant users who were depressed (95% CI = 2.37-5.55). All durations of use were associated with incident frailty (<1 year OR = 1.95, 95% CI = 1.41-2.68; 1-3 years OR = 1.99, 95% CI = 1.45-2.74; >3 years OR = 1.60, 95% CI = 1.20-2.14).

CONCLUSION: In older adult women, depressive symptoms and antidepressant use were associated with frailty after 3 years of follow-up.

Author List

Lakey SL, LaCroix AZ, Gray SL, Borson S, Williams CD, Calhoun D, Goveas JS, Smoller JW, Ockene JK, Masaki KH, Coday M, Rosal MC, Woods NF

Author

Joseph S. Goveas MD Professor in the Psychiatry department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Antidepressive Agents
Depression
Female
Frail Elderly
Humans
Middle Aged
Prospective Studies
Women's Health