The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science 2020 Sep 11;369(6509):1388-1394
Date
08/01/2020Pubmed ID
32732282Pubmed Central ID
PMC7849028DOI
10.1126/science.aba8984Scopus ID
2-s2.0-85090870608 (requires institutional sign-in at Scopus site) 151 CitationsAbstract
Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for rhythmicity and their effects on physiology are not well understood. We show that deletion of core clock components REV-ERBĪ± and REV-ERBĪ² in adult mouse hepatocytes disrupts diurnal rhythms of a subset of liver genes and alters the diurnal rhythm of de novo lipogenesis. Liver function is also influenced by nonhepatocytic cells, and the loss of hepatocyte REV-ERBs remodels the rhythmic transcriptomes and metabolomes of multiple cell types within the liver. Finally, alteration of food availability demonstrates the hierarchy of the cell-intrinsic hepatocyte clock mechanism and the feeding environment. Together, these studies reveal previously unsuspected roles of the hepatocyte clock in the physiological coordination of nutritional signals and cell-cell communication controlling rhythmic metabolism.
Author List
Guan D, Xiong Y, Trinh TM, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz JD, Lazar MAAuthor
Yang Xiao Assistant Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Communication
Circadian Clocks
Circadian Rhythm
Feeding Behavior
Gene Deletion
Gene Expression Regulation
Hepatocytes
Liver
Mice
Mice, Inbred C57BL
Mice, Knockout
Nuclear Receptor Subfamily 1, Group D, Member 1
Receptors, Cytoplasmic and Nuclear
Repressor Proteins
