Heart rate perturbation in the stage 17-27 chick embryo: effect on stroke volume and aortic flow. Am J Physiol 1993 Mar;264(3 Pt 2):H755-9
Date
03/11/1993Pubmed ID
8456978DOI
10.1152/ajpheart.1993.264.3.H755Scopus ID
2-s2.0-0027412569 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Heart rate (HR), stroke volume (SV), and aortic flow increase linearly between developmental stages 17 and 27, as the embryonic chick heart progresses from a bent tube to a rudimentary four-chambered structure and cardiac mass increases fourfold. We hypothesized that HR perturbation, expressed as percent of intrinsic HR (%HR), would have a developmentally dependent effect on flow and SV. HR was transiently perturbed to 40-250% of intrinsic rate with a 1-mm cooled or heated steel probe applied to the sinus venosus of 81 embryos. Aortic blood velocity, cross-sectional area, and HR were used to calculate flow and SV. At each stage, flow was maximal at intrinsic HR. The %HR vs. SV relationship was linear, inverse, and developmentally dependent. In spite of a tremendous change in ventricular shape, mass, and volume, HR control during development of the preinnervated heart maximizes blood flow to the developing embryo.
Author List
Cuneo B, Hughes S, Benson DW JrMESH terms used to index this publication - Major topics in bold
AnimalsAorta
Blood Flow Velocity
Chick Embryo
Heart
Heart Rate
Stroke Volume
Time Factors
