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Adenovirus persistence in man. Defective E1A gene product targeting of infected cells for elimination by natural killer cells. J Immunol 1989 Jun 01;142(11):4022-6



Pubmed ID


Scopus ID

2-s2.0-0024372775   7 Citations


Human adenovirus types 2 and 5 (Ad2/5) cause persistent infections in man. Ad2/5 infection of rodent cells induces increased susceptibility to NK lymphocyte-mediated lysis that is dependent on target cell expression of Ad2/5 E1A gene products. In contrast to infected rodent cells, Ad2/5 infection of human fibroblasts and epithelial cells does not result in increased susceptibility to either human or rodent NK cell-mediated killing, despite high levels of E1A protein expression. This functional inactivity of E1A gene products in Ad-infected human cells may contribute to adenoviral persistence by rendering the NK cell response to Ad-infected cells ineffective.

Author List

Routes JM, Cook JL

MESH terms used to index this publication - Major topics in bold

Adenoviridae Infections
Adenovirus Early Proteins
Adenovirus Infections, Human
Cell Line
Cytotoxicity, Immunologic
Immunity, Cellular
Immunity, Innate
Killer Cells, Natural
Molecular Weight
Oncogene Proteins, Viral
Species Specificity