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Adenovirus persistence in man. Defective E1A gene product targeting of infected cells for elimination by natural killer cells. J Immunol 1989 Jun 01;142(11):4022-6

Date

06/01/1989

Pubmed ID

2541204

Scopus ID

2-s2.0-0024372775   7 Citations

Abstract

Human adenovirus types 2 and 5 (Ad2/5) cause persistent infections in man. Ad2/5 infection of rodent cells induces increased susceptibility to NK lymphocyte-mediated lysis that is dependent on target cell expression of Ad2/5 E1A gene products. In contrast to infected rodent cells, Ad2/5 infection of human fibroblasts and epithelial cells does not result in increased susceptibility to either human or rodent NK cell-mediated killing, despite high levels of E1A protein expression. This functional inactivity of E1A gene products in Ad-infected human cells may contribute to adenoviral persistence by rendering the NK cell response to Ad-infected cells ineffective.

Author List

Routes JM, Cook JL



MESH terms used to index this publication - Major topics in bold

Adenoviridae Infections
Adenovirus Early Proteins
Adenovirus Infections, Human
Animals
Cell Line
Cricetinae
Cytotoxicity, Immunologic
Humans
Immunity, Cellular
Immunity, Innate
Killer Cells, Natural
Mesocricetus
Molecular Weight
Oncogene Proteins, Viral
Species Specificity