Faculty Collaboration Database

Hormonal reactivity to MRI scanning in adolescents. Psychoneuroendocrinology 2009 Sep;34(8):1242-6

Date

04/07/2009

Pubmed ID

19346079

Pubmed Central ID

PMC2747582

DOI

10.1016/j.psyneuen.2009.03.006

Scopus ID

2-s2.0-67650602116 (requires institutional sign-in at Scopus site)   73 Citations

Abstract

Magnetic resonance imaging (MRI) is a procedure that is now widely used to study emotional and cognitive processes in children and adolescents. However, the context within which brain imaging data are collected is a social context that may induce anxiety and stress. Several hormones have been shown to be responsive to environmental stressors. These stress responses may impact ability to successfully complete the procedure or collect imaging data. To investigate these issues, we measured salivary cortisol, dehydroepiandrosterone (DHEA), and testosterone in 160 adolescents during both a simulation (practice) and actual MRI. Hormones were all responsive to the MRI scan, indicating that an MRI scan itself can induce a stress response, with some hormones predicting the likelihood that an adolescent could successfully complete the scan with adequate data. The simulation scan did not hinder hormonal responses to the actual MRI. These data suggest that researchers should consider the effects of heightened hormonal reactivity to the scanning environment; adolescent's reactions to brain imaging may contribute to image data loss and may potentially influence outcome measures.

Author List

Eatough EM, Shirtcliff EA, Hanson JL, Pollak SD

Author

Jamie Hanson PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Child
Dehydroepiandrosterone
Female
Humans
Hydrocortisone
Magnetic Resonance Imaging
Male
Saliva
Stress, Psychological
Testosterone