Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients. Carcinogenesis 2012 Sep;33(9):1797-805
Date
06/15/2012Pubmed ID
22696596Pubmed Central ID
PMC3514907DOI
10.1093/carcin/bgs210Scopus ID
2-s2.0-84865569656 (requires institutional sign-in at Scopus site) 54 CitationsAbstract
Lung cancer has become the top killer among malignant tumors in China and is significantly associated with somatic genetic alterations. We performed exome sequencing of 14 non-small cell lung carcinomas (NSCLCs) with matched adjacent normal lung tissues extracted from Chinese patients. In addition to the lung cancer-related genes (TP53, EGFR, KRAS, PIK3CA, and ROS1), this study revealed "novel" genes not previously implicated in NSCLC. Especially, matrix-remodeling associated 5 was the second most frequently mutated gene in NSCLC (first is TP53). Subsequent Sanger sequencing of matrix-remodeling associated 5 in an additional sample set consisting of 52 paired tumor-normal DNA samples revealed that 15% of Chinese NSCLCs contained somatic mutations in matrix-remodeling associated 5. These findings, together with the results from pathway analysis, strongly indicate that altered extracellular matrix-remodeling may be involved in the etiology of NSCLC.
Author List
Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You MMESH terms used to index this publication - Major topics in bold
Antigens, NuclearCarcinoma, Non-Small-Cell Lung
Cell Cycle Proteins
Exome
Genes, Neoplasm
Humans
Lung Neoplasms
Mutation
Proteoglycans
