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5'-Peptidyl substituents allow a tuning of the affinity of oligodeoxyribonucleotides for RNA. Bioorg Med Chem Lett 1998 Sep 22;8(18):2511-6

Date

01/05/1999

Pubmed ID

9873571

DOI

10.1016/s0960-894x(98)00449-1

Scopus ID

2-s2.0-0032558529   16 Citations

Abstract

The affinity of amide-linked 5'-aminoacyl and 5'-dipeptidyl DNA octamers for two RNA undecamers with 3'-overhangs was measured via UV melting analysis. A sequence-dependent increase in melting points was observed. At low ionic strength, two appended lysine residues elevate melting points more than two additional A:U base pairs.

Author List

Sarracino DA, Steinberg JA, Vergo MT, Woodworth GF, Tetzlaff CN, Richert C

Author

Joshua A. Steinberg MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Circular Dichroism
DNA
Dipeptides
Magnetic Resonance Spectroscopy
Nucleic Acid Conformation
Oligodeoxyribonucleotides
Osmolar Concentration
RNA
Spectrophotometry, Ultraviolet