Faculty Collaboration Database

Mucin production and mucous cell metaplasia in otitis media. Int J Otolaryngol 2012;2012:745325

Date

06/12/2012

Pubmed ID

22685463

Pubmed Central ID

PMC3364788

DOI

10.1155/2012/745325

Abstract

Otitis media (OM) with mucoid effusion, characterized by mucous cell metaplasia/hyperplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a subtype of OM which frequently leads to chronic OM in young children. Multiple factors are involved in the developmental process of OM with mucoid effusion, especially disorders of mucin production resulting from middle ear bacterial infection and Eustachian tube dysfunction. In this review, we will focus on several aspects of this disorder by analyzing the cellular and molecular events such as mucin production and mucous cell differentiation in the middle ear mucosa with OM. In addition, infectious agents, mucin production triggers, and relevant signaling pathways will be discussed.

Author List

Lin J, Caye-Thomasen P, Tono T, Zhang QA, Nakamura Y, Feng L, Huang J, Ye S, Hu X, Kerschner JE

Author

Joseph E. Kerschner MD Provost, Executive Vice President, Dean, Professor in the School of Medicine Administration department at Medical College of Wisconsin