Haplogroup-associated differences in neonatal death and incidence of low birth weight at elevation: a preliminary assessment. Am J Obstet Gynecol 2000 Jun;182(6):1599-605
Date
06/28/2000Pubmed ID
10871483DOI
10.1067/mob.2000.107331Scopus ID
2-s2.0-0033937671 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
OBJECTIVE: We sought to assess reproductive fitness differences between mitochondrial deoxyribonucleic acid haplogroups at high altitude.
STUDY DESIGN: This study considers differences in outcomes of conception, birth weight, and neonatal mortality rates for 62 women classified according to haplogroups (B or non-B).
RESULTS: The number of low-weight births (<2500 g) for the non-B group was significant (P =.019). Mothers in the non-B group reported more spontaneous abortions (P =.171) and stillbirths (P =.301). The difference in conceptions per woman between groups was significant (P =.036). However, no difference in infants alive at 1 month of age was evident. Neonatal death was significant (P =.017). The odds of an unsuccessful outcome among mothers in the B group was compared with mothers in the non-B group and was significant (P =.029). The chance of an adverse outcome, that is, fetal or infant death before 1 month, for mothers in the B group was between 11.1% and 88.7% lower than for mothers in the non-B group.
CONCLUSIONS: The neonatal mortality rate for the non-B group was significantly elevated relative to the B group. The molecular basis for these observations is not clear.
Author List
Myres JE, Malan M, Shumway JB, Rowe MJ, Amon E, Woodward SRAuthor
Michael J. Malan MD Assistant Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Abortion, HabitualAdult
Altitude
Birth Weight
DNA, Mitochondrial
Female
Fertilization
Fetal Death
Haplotypes
Humans
Incidence
Infant Mortality
Infant, Low Birth Weight
Infant, Newborn
Medical Records
Pregnancy
Pregnancy Complications
Pregnancy Outcome
Risk Factors