Reproductive toxicity of acrylamide-treated male rats. Reprod Toxicol 2010 Apr;29(2):225-30
Date
11/12/2009Pubmed ID
19903525DOI
10.1016/j.reprotox.2009.11.002Scopus ID
2-s2.0-77949567525 (requires institutional sign-in at Scopus site) 106 CitationsAbstract
Acrylamide content is elevated in fried, baked and heat-processed starchy foods. The present experiment was conducted to investigate the reproductive toxicity of oral acrylamide in male rats. Thirty weaned SD male rats of 21-day-old were randomly allotted to three groups, and acrylamide was administered to each group at doses of 0, 5 and 10 mg/kg-d for 8 consecutive weeks. The results indicated that the growth of rats treated with acrylamide was retarded (P<0.05), but relative weights of testes and epididymides compared to body weight were not significantly different (P>0.05). Our results also indicate that the epididymal sperm reserves decreased significantly (P<0.05), suggesting partial depletion of germ cells. In addition, histopathologic lesions were also present in the testes of treated rats. Furthermore, distinct expression patterns of sGC heterodimers were observed in this animal model. This may suggest different physiologic roles for sGC subunits in spermiogenesis and steroidogenesis.
Author List
Wang H, Huang P, Lie T, Li J, Hutz RJ, Li K, Shi FAuthor
Reinhold J. Hutz in the Biological Sciences department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AcrylamideAnimals
Body Weight
Epididymis
Growth
Guanylate Cyclase
Hyperplasia
Immunohistochemistry
Leydig Cells
Male
Organ Size
Protein Multimerization
Rats
Rats, Sprague-Dawley
Receptors, Cytoplasmic and Nuclear
Soluble Guanylyl Cyclase
Spermatozoa
Testis
Testosterone