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Default mode network abnormalities in idiopathic generalized epilepsy. Epilepsy Behav 2012 Mar;23(3):353-9

Date

03/03/2012

Pubmed ID

22381387

Pubmed Central ID

PMC4407647

DOI

10.1016/j.yebeh.2012.01.013

Scopus ID

2-s2.0-84858287571   70 Citations

Abstract

Idiopathic generalized epilepsy (IGE) is associated with widespread cortical network abnormalities on electroencephalography. Resting state functional connectivity (RSFC), based on fMRI, can assess the brain's global functional organization and its disruption in clinical conditions. We compared RSFC associated with the 'default mode network' (DMN) between people with IGE and healthy controls. Strength of functional connectivity within the DMN associated with seeds in the posterior cingulate cortex (PCC) and medial prefrontal cortices (MPFC) was compared between people with IGE and healthy controls and was correlated with seizure duration, age of seizure onset and age at scan. Those with IGE showed markedly reduced functional network connectivity between anterior and posterior cortical seed regions. Seizure duration positively correlates with RSFC between parahippocampal gyri and the PCC but negatively correlates with connectivity between the PCC and frontal lobe. The observed pattern of disruption provides evidence for integration- and segregation-type network abnormalities and supports aberrant network organization among people with IGE.

Author List

McGill ML, Devinsky O, Kelly C, Milham M, Castellanos FX, Quinn BT, DuBois J, Young JR, Carlson C, French J, Kuzniecky R, Halgren E, Thesen T

Author

Chad Carlson MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Brain Mapping
Case-Control Studies
Cerebral Cortex
Electroencephalography
Epilepsy, Generalized
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways
Oxygen
Young Adult