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Ranibizumab treatment outcomes in phakic versus pseudophakic eyes: an individual patient data analysis of 2 phase 3 trials. Ophthalmology 2013 Jun;120(6):1278-82



Pubmed ID




Scopus ID

2-s2.0-84878554365 (requires institutional sign-in at Scopus site)   14 Citations


OBJECTIVE: To compare visual outcomes in phakic and pseudophakic eyes treated with monthly intravitreal ranibizumab for exudative age-related macular degeneration (AMD).

DESIGN: Meta-analysis of individual patient data from 2 phase 3 clinical trials of intravitreal ranibizumab in neovascular AMD (Anti-VEGF Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization in Age-Related Macular Degeneration [ANCHOR], number, NCT00061594; and Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab in the Treatment of Neovascular Age-Related Macular Degeneration [MARINA], number NCT00056836).

PARTICIPANTS AND CONTROLS: A total of 1137 patients from 2 phase 3 clinical trials.

METHODS: Phakic and pseudophakic eyes were treated with monthly intravitreal ranibizumab (0.3 mg or 0.5 mg), sham injections plus verteporfin photodynamic therapy (ANCHOR), or sham injections alone (MARINA).

MAIN OUTCOME MEASURES: Mean change from baseline in Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity (VA) and the proportion of patients gaining or losing 15 or more ETDRS letters.

RESULTS: After adjusting for baseline covariates, no differences were seen in mean change in VA for phakic versus pseudophakic eyes. Pseudophakic eyes were more likely to lose 15 or more letters of vision than phakic eyes at 12 months, but not at 24 months.

CONCLUSIONS: Overall, in this analysis, lens status did not demonstrate an independent influence on mean VA for eyes treated with monthly ranibizumab. It is possible that phakic eyes may be less prone to severe vision loss.

FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

Author List

Weinberg DV, Shapiro H, Ehrlich JS


David V. Weinberg MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged, 80 and over
Angiogenesis Inhibitors
Antibodies, Monoclonal, Humanized
Clinical Trials, Phase III as Topic
Intravitreal Injections
Lens, Crystalline
Photosensitizing Agents
Treatment Outcome
Visual Acuity
Wet Macular Degeneration