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Severe thrombocytopenia in a child secondary to passive platelet antibody transfer from a plasma transfusion. J Pediatr Hematol Oncol 2013 Jul;35(5):e226-8

Date

03/06/2013

Pubmed ID

23459377

Pubmed Central ID

PMC4508016

DOI

10.1097/MPH.0b013e3182830c25

Abstract

Although rare, passive transfer of platelet antibodies through blood products can result in thrombocytopenia, acute transfusion reactions, and death. We report a case of severe alloimmune thrombocytopenia from a plasma transfusion. A postliver transplant patient with a normal platelet count received fresh frozen plasma before liver biopsy. Postbiopsy, she developed cardiorespiratory distress, petechiae, and severe thrombocytopenia (platelet count 2000/μL). Her platelet count recovered to normal after 1 week. This diagnosis should be considered whenever an unexpected drop in the platelet count occurs after a plasma-rich transfusion. Conservative transfusion practices and more targeted donor screening may prevent similar events.

Author List

Collins CL, Scott JP, Panepinto JA, Punzalan RC

Authors

Julie A. Panepinto MD, MSPH Professor in the Pediatrics department at Medical College of Wisconsin
Rowena C. Punzalan MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
John Paul Scott MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Antigens, Human Platelet
Blood Component Transfusion
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Isoantibodies
Liver Transplantation
Plasma
Thrombocytopenia
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a