Monoamine oxidase types A and B in the vertebrate brain. Comp Biochem Physiol C Comp Pharmacol 1982;71C(1):107-10
Date
01/01/1982Pubmed ID
6121664DOI
10.1016/0306-4492(82)90018-1Scopus ID
2-s2.0-0020041430 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
1. Monoamine oxidase (MAO) activity was measured in brains of teleosts, amphibians a reptile, birds and mammals. Selective inhibitors were used to determine the relative proportion of MAO type A and MAO type B. 2. Brain homogenates of all tetrapods showed double sigmoid inhibition curves, indicating the presence of both forms of MAO. 3. Brain homogenates of all teleosts showed single sigmoid inhibition curves, with greater sensitivity to type A inhibitors. 4. These results indicate that tetrapod brains contain both type A and type B MAO activity, whereas teleost brains contain only a type A-like enzyme. 5. It is possible that the presence of two forms of MAO in brain may confer an advantage to a terrestrial lifestyle.
Author List
Hall TR, Yurgens PB, Figueroa HR, Urueña G, Olcese JM, Newton DK, Vorwald SRAuthor
Debra K. Newman PhD Investigator in the Blood Research Institute department at BloodCenter of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBrain
Chickens
Columbidae
Fishes
Goldfish
Male
Monoamine Oxidase
Rana catesbeiana
Rana pipiens
Rats
Rats, Inbred Strains
Species Specificity
Trout
Turtles
