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Ischemia-induced changes in myocardial paramagnetic metabolites: implications for intracellular oxy-radical generation. FEBS Lett 1989 Feb 27;244(2):311-4

Date

02/27/1989

Pubmed ID

2537756

DOI

10.1016/0014-5793(89)80552-6

Scopus ID

2-s2.0-0024561513   42 Citations

Abstract

Evidence to identify the cellular sources of oxy-radical generation in myocardium has been of an indirect nature. We have used low-temperature ESR spectroscopy to identify and characterize ischemia-induced changes in myocardial paramagnetic metabolites. Iron-sulfur proteins associated with the NADH or succinate dehydrogenases of the mitochondrial electron-transport chain were progressively reduced with the onset and development of ischemia. This study provides direct evidence for ischemia-induced changes in an intracellular source of superoxide radical generation that may contribute to oxy-radical production during reperfusion.

Author List

Baker JE, Kalyanaraman B

Authors

John E. Baker PhD Professor in the Surgery department at Medical College of Wisconsin
Balaraman Kalyanaraman PhD Chair, Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Coronary Disease
Electron Spin Resonance Spectroscopy
Free Radicals
In Vitro Techniques
Models, Biological
Myocardium
Perfusion
Rats
Rats, Inbred Strains
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a