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Reductive stress on life span extension in C. elegans. BMC Res Notes 2008 Jun 04;1:19

Date

08/20/2008

Pubmed ID

18710529

Pubmed Central ID

PMC2518267

DOI

10.1186/1756-0500-1-19

Abstract

Recently, Schulz and colleagues have contributed to the ongoing controversy on the unproven role of oxidative stress in the aging process in their well-performed study 'Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress' (Cell Metab 2007, 6: 280-293). Here, we suggest an alternative hypothesis that reductive stress can prevent calorie-restriction induced life span extension. We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants.

Author List

Ralser M, Benjamin IJ

Author

Ivor J. Benjamin MD Center Director, Professor in the Medicine department at Medical College of Wisconsin




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