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Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci U S A 1996 Mar 19;93(6):2339-42

Date

03/19/1996

Pubmed ID

8637874

Pubmed Central ID

PMC39797

DOI

10.1073/pnas.93.6.2339

Scopus ID

2-s2.0-9244263563   236 Citations

Abstract

Heat shock proteins are proposed to limit injury resulting from diverse environmental stresses, but direct metabolic evidence for such a cytoprotective function in vertebrates has been largely limited to studies of cultured cells. We generated lines of transgenic mice to express human 70-kDa heat shock protein constitutively in the myocardium. Hearts isolated from these animals demonstrated enhanced recovery of high energy phosphate stores and correction of metabolic acidosis following brief periods of global ischemia sufficient to induce sustained abnormalities of these variables in hearts from nontransgenic littermates. These data demonstrate a direct cardioprotective effect of 70-kDa heat shock protein to enhance postischemic recovery of the intact heart.

Author List

Radford NB, Fina M, Benjamin IJ, Moreadith RW, Graves KH, Zhao P, Gavva S, Wiethoff A, Sherry AD, Malloy CR, Williams RS

Author

Ivor J. Benjamin MD Center Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adenine Nucleotides
Animals
Energy Metabolism
HSP70 Heat-Shock Proteins
Humans
Magnetic Resonance Spectroscopy
Mice
Mice, Transgenic
Myocardium
Reperfusion Injury
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a