Effects of anesthetics, sedatives, and opioids on ventilatory control. Compr Physiol 2012 Oct;2(4):2281-367
Date
05/31/2013Pubmed ID
23720250DOI
10.1002/cphy.c100061Scopus ID
2-s2.0-84891708026 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
This article provides a comprehensive, up to date summary of the effects of volatile, gaseous, and intravenous anesthetics and opioid agonists on ventilatory control. Emphasis is placed on data from human studies. Further mechanistic insights are provided by in vivo and in vitro data from other mammalian species. The focus is on the effects of clinically relevant agonist concentrations and studies using pharmacological, that is, supraclinical agonist concentrations are de-emphasized or excluded.
Author List
Stuth EA, Stucke AG, Zuperku EJAuthors
Astrid G. Stucke MD Professor in the Anesthesiology department at Medical College of WisconsinEckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin
Edward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Analgesics, OpioidAnesthetics, General
Animals
Carotid Body
Chemoreceptor Cells
Dose-Response Relationship, Drug
Humans
Hypnotics and Sedatives
Ion Channels
Models, Animal
Motor Neurons
Respiratory Center
Respiratory Mechanics
Synaptic Transmission