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Recognition of famous names predicts cognitive decline in healthy elders. Neuropsychology 2013 May;27(3):333-42

Date

05/22/2013

Pubmed ID

23688215

Pubmed Central ID

PMC3798037

DOI

10.1037/a0032226

Scopus ID

2-s2.0-84881004216   14 Citations

Abstract

OBJECTIVE: The ability to recognize familiar people is impaired in both Mild Cognitive Impairment (MCI) and Alzheimer's Dementia (AD). In addition, both groups often demonstrate a time-limited temporal gradient (TG) in which well known people from decades earlier are better recalled than those learned recently. In this study, we examined the TG in cognitively intact elders for remote famous names (1950-1965) compared to more recent famous names (1995-2005). We hypothesized that the TG pattern on a famous name recognition task (FNRT) would predict future cognitive decline, and also show a significant correlation with hippocampal volume.

METHOD: Seventy-eight healthy elders (ages 65-90) with age-appropriate cognitive functioning at baseline were administered a FNRT. Follow-up testing 18 months later produced two groups: Declining (a?Y 1 SD reduction on at least one of three measures) and Stable (< 1 SD).

RESULTS: The Declining group (N = 27) recognized fewer recent famous names than the Stable group (N = 51), although recognition for remote names was comparable. Baseline MRI volumes for both the left and right hippocampi were significantly smaller in the Declining group than the Stable group. Smaller baseline hippocampal volume was also significantly correlated with poorer performance for recent, but not remote famous names. Logistic regression analyses indicated that baseline TG performance was a significant predictor of group status (Declining vs. Stable) independent of chronological age and APOE I?4 inheritance.

CONCLUSIONS: The TG for famous name recognition may serve as an early preclinical cognitive marker of cognitive decline in healthy older individuals.

Author List

Seidenberg M, Kay CD, Woodard JL, Nielson KA, Smith JC, Kandah C, Guidotti Breting LM, Novitski J, Lancaster M, Matthews M, Hantke N, Butts A, Rao SM

Authors

Alissa Butts PhD Assistant Professor in the Neurology department at Medical College of Wisconsin
Kristy Nielson PhD Professor in the Psychology department at Marquette University




MESH terms used to index this publication - Major topics in bold

Aged
Aged, 80 and over
Alzheimer Disease
Brain
Cognition Disorders
Cognitive Dysfunction
Early Diagnosis
Female
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Predictive Value of Tests