Faculty Collaboration Database

Postmenopausal hormone therapy: a concise guide to therapeutic uses, formulations, risks, and alternatives. Prim Care 2003 Dec;30(4):671-96

Date

03/18/2004

Pubmed ID

15024891

DOI

10.1016/s0095-4543(03)00093-9

Scopus ID

2-s2.0-0347694847 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Postmenopausal hormone replacement therapy is helpful in relieving menopausal vasomotor symptoms and vaginal atrophy and can prevent osteoporosis; however, attendant risks include breast cancer, thromboembolism, gallbladder disease, stroke, CHD, dementia, and hypertriglyceridemia. Decision making must weigh these risks and benefits and also include potential benefits on mood, colorectal cancer prevention, and hip fracture reduction. Some areas, such as ovarian cancer risk and the impact of combination estrogen-progestin versus unopposed estrogen on risk, remain unclear. The physician and patient need to carefully assess, discuss, and monitor the individual's symptoms and risks when considering HT use. For those with contraindications or concerns about HT, there are alternative therapies of variable efficacy for vasomotor symptoms and vaginal atrophy.

Author List

Mitchell JL, Walsh J, Wang-Cheng R, Hardman JL

Author

Julie L. Mitchell MD Adjunct Professor in the Family Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Alzheimer Disease
Cardiovascular Diseases
Colorectal Neoplasms
Coronary Disease
Diabetes Mellitus
Estrogen Replacement Therapy
Humans
Hyperlipidemias
Neoplasms
Osteoporosis, Postmenopausal
Stroke
Thromboembolism
Urinary Tract Infections
Urogenital System