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Relations of depressive symptoms and antidepressant use to body mass index and selected biomarkers for diabetes and cardiovascular disease. Am J Public Health 2013 Aug;103(8):e34-43

Date

06/15/2013

Pubmed ID

23763394

Pubmed Central ID

PMC3791588

DOI

10.2105/AJPH.2013.301394

Scopus ID

2-s2.0-84880179707 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

OBJECTIVES: We investigated whether depressive symptoms and antidepressant use are associated with biomarkers for glucose dysregulation and inflammation, body mass index (BMI), and waist circumference.

METHODS: Postmenopausal women were recruited into the Women's Health Initiative from 1993 to 1998, and data were collected at regular intervals through 2005. We used multiple linear regression models to examine whether depressive symptoms and antidepressant use are associated with BMI, waist circumference, and biomarkers.

RESULTS: Analysis of data from 71, 809 women who completed all relevant baseline and year 3 assessments showed that both elevated depressive symptoms and antidepressant use were significantly associated with higher BMI and waist circumference. Among 1950 women, elevated depressive symptoms were significantly associated with increased insulin levels and measures of insulin resistance. Analyses of baseline data from 2242 women showed that both elevated depressive symptoms and antidepressant use were associated with higher C-reactive protein levels.

CONCLUSIONS: Monitoring body habitus and other biomarkers among women with elevated depression symptoms or taking antidepressant medication may be prudent to prevent diabetes and cardiovascular disease.

Author List

Ma Y, Balasubramanian R, Pagoto SL, Schneider KL, Hébert JR, Phillips LS, Goveas JS, Culver AL, Olendzki BC, Beck J, Smoller JW, Sepavich DM, Ockene JK, Uebelacker L, Zorn M, Liu S

Author

Joseph S. Goveas MD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Antidepressive Agents
Biomarkers
Blood Glucose
Body Height
Body Mass Index
Body Weight
C-Reactive Protein
Cardiovascular Diseases
Depression
Diabetes Mellitus, Type 2
Female
Humans
Inflammation
Insulin
Insulin Resistance
Interleukin-6
Linear Models
Lipids
Middle Aged
Postmenopause
Tumor Necrosis Factor-alpha
Waist Circumference