Across the developmental continuum of irritable bowel syndrome: clinical and pathophysiologic considerations. Curr Gastroenterol Rep 2004 Jun;6(3):247-53
Date
05/07/2004Pubmed ID
15128493DOI
10.1007/s11894-004-0015-4Scopus ID
2-s2.0-4544378724 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Irritable bowel syndrome is a common functional gastrointestinal disorder that affects children and adults. The lack of consensus diagnostic criteria and pathophysiologic understanding has hampered clinical progress in diagnosing and treating this disorder. The recent development of the Rome diagnostic criteria, mapping of brain-gut pathways using neuroimaging, and serotonergic pharmacology have greatly advanced the field. Chronic and acute life stress, especially during childhood, has been recognized as central to the initiation of the disorder and the induction of acute symptoms. We propose a developmental continuum whereby the clinical presentation of irritable bowel syndrome changes with age from irritability during infancy, to diarrhea in toddlers, to recurring abdominal pain during school age, and to pain and altered bowel habits during later adolescence and adulthood.
Author List
Besedovsky A, Li BUAuthor
B Ulysses Kwang Li Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Abdominal PainAdult
Child
Diarrhea, Infantile
Gastrointestinal Motility
Humans
Infant
Irritable Bowel Syndrome
Risk Factors
