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On coupling a lumped parameter heart model and a three-dimensional finite element aorta model. Ann Biomed Eng 2009 Nov;37(11):2153-69

Date

07/18/2009

Pubmed ID

19609676

DOI

10.1007/s10439-009-9760-8

Scopus ID

2-s2.0-70349659716 (requires institutional sign-in at Scopus site)   251 Citations

Abstract

Aortic flow and pressure result from the interactions between the heart and arterial system. In this work, we considered these interactions by utilizing a lumped parameter heart model as an inflow boundary condition for three-dimensional finite element simulations of aortic blood flow and vessel wall dynamics. The ventricular pressure-volume behavior of the lumped parameter heart model is approximated using a time varying elastance function scaled from a normalized elastance function. When the aortic valve is open, the coupled multidomain method is used to strongly couple the lumped parameter heart model and three-dimensional arterial models and compute ventricular volume, ventricular pressure, aortic flow, and aortic pressure. The shape of the velocity profiles of the inlet boundary and the outlet boundaries that experience retrograde flow are constrained to achieve a robust algorithm. When the aortic valve is closed, the inflow boundary condition is switched to a zero velocity Dirichlet condition. With this method, we obtain physiologically realistic aortic flow and pressure waveforms. We demonstrate this method in a patient-specific model of a normal human thoracic aorta under rest and exercise conditions and an aortic coarctation model under pre- and post-interventions.

Author List

Kim HJ, Vignon-Clementel IE, Figueroa CA, LaDisa JF, Jansen KE, Feinstein JA, Taylor CA

Author

John F. LaDisa PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Aorta
Blood Flow Velocity
Blood Pressure
Computer Simulation
Finite Element Analysis
Humans
Models, Cardiovascular
Stroke Volume
Vascular Capacitance
Vascular Resistance
Ventricular Function, Left