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Effects of intraocular mescaline and LSD on visual-evoked responses in the rat. Pharmacol Biochem Behav 1989 Jan;32(1):191-6

Date

01/01/1989

Pubmed ID

2734330

DOI

10.1016/0091-3057(89)90232-3

Scopus ID

2-s2.0-0024504950 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

The effects of mescaline and LSD on the flash-evoked cortical potential (FEP) were determined in unrestrained rats with chronically-implanted electrodes. Systemic administration of mescaline or LSD significantly attenuated the primary component of the FEP at three stimulus intensities with the greatest effect observed 60-90 minutes following drug administration. The magnitude and specificity of the effects of these agents on the primary response suggest that they produce deficits in conduction through the retino-geniculato-cortical system. The serotonin receptor antagonists, cyproheptadine and methysergide, antagonized the mescaline-induced depression of the FEP in accordance with neurochemical and behavioral evidence that mescaline acts as a partial agonist on serotonin receptors. Topical or intraocular administration of atropine antagonized the actions of systemically-administered mescaline. In addition, intraocular administration of mescaline or LSD attenuated the FEP indicative of an action of these hallucinogens on visual processing in the retina which is modulated by muscarinic receptor activity.

Author List

Eells JT, Wilkison DM

Author

Janis Eells PhD Professor in the Biomedical Sciences department at University of Wisconsin - Milwaukee




MESH terms used to index this publication - Major topics in bold

Administration, Topical
Animals
Atropine
Cyproheptadine
Electrodes, Implanted
Evoked Potentials, Visual
Eye
Injections
Lysergic Acid Diethylamide
Mescaline
Methysergide
Phenylephrine
Rats
Rats, Inbred Strains