Estradiol-induced enhancement of object memory consolidation involves NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice. Behav Neurosci 2008 Jun;122(3):716-21
Date
06/03/2008Pubmed ID
18513142Pubmed Central ID
PMC2673328DOI
10.1037/0735-7044.122.3.716Scopus ID
2-s2.0-44649125951 (requires institutional sign-in at Scopus site) 96 CitationsAbstract
This study examined the role of dorsal hippocampal NMDA receptors and PKA activation in 17 beta-estradiol (E2)-induced enhancement of object memory consolidation. Mice explored two identical objects during training, after which they immediately received intraperitoneal injections of 0.2 mg/kg E2, and bilateral dorsal hippocampal infusions of Vehicle, the NMDA receptor antagonist APV (2.5 microg/side), or the cAMP inhibitor Rp-cAMPS (18.0 microg/side). Retention was tested 48 hours later. The enhanced object memory and increased ERK phosphorylation observed with E2 alone was reduced by APV and Rp-cAMPS, suggesting that estrogenic enhancement of object memory involves NMDA receptors and PKA activation within the dorsal hippocampus.
Author List
Lewis MC, Kerr KM, Orr PT, Frick KMAuthor
Karyn Frick BA,MA,PhD Professor in the Psychology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AnimalsBehavior, Animal
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Drug Interactions
Estradiol
Estrogens
Excitatory Amino Acid Antagonists
Extracellular Signal-Regulated MAP Kinases
Female
Hippocampus
Memory
Mice
Mice, Inbred C57BL
Ovariectomy
Pattern Recognition, Visual
Photic Stimulation
Protein Kinase Inhibitors
Receptors, N-Methyl-D-Aspartate
Thionucleotides
Valine
