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Sleep deprivation in the rat: X. Integration and discussion of the findings. Sleep 1989 Feb;12(1):68-87

Date

02/01/1989

Pubmed ID

2648533

Scopus ID

2-s2.0-0024497467 (requires institutional sign-in at Scopus site)   324 Citations

Abstract

The results of a series of studies on total and selective sleep deprivation in the rat are integrated and discussed. These studies showed that total sleep deprivation, paradoxical sleep deprivation, and disruption and/or deprivation of non-rapid eye movement (NREM) sleep produced a reliable syndrome that included death, debilitated appearance, skin lesions, increased food intake, weight loss, increased energy expenditure, decreased body temperature during the late stages of deprivation, increased plasma norepinephrine, and decreased plasma thyroxine. The significance of this syndrome for the function of sleep is not entirely clear, but several changes suggested that sleep may be necessary for effective thermoregulation.

Author List

Rechtschaffen A, Bergmann BM, Everson CA, Kushida CA, Gilliland MA

Author

Carol A. Everson PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Arousal
Body Temperature Regulation
Cerebral Cortex
Electroencephalography
Energy Metabolism
Hormones
Humans
Rats
Sleep Deprivation
Sleep Stages