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Sleep deprivation in the rat: I. Conceptual issues. Sleep 1989 Feb;12(1):1-4

Date

02/01/1989

Pubmed ID

2648532

DOI

10.1093/sleep/12.1.1

Scopus ID

2-s2.0-0024494517 (requires institutional sign-in at Scopus site)   37 Citations

Abstract

Sleep deprivation is a potentially powerful strategy for discovering the function(s) of sleep, but the approach has had limited success. Few studies have described serious physiological consequences of sleep deprivation, perhaps because the deprivation has not been maintained long enough. However, prolonging deprivation usually requires sustained, frequently intense stimulation, which makes it difficult to determine whether subsequent impairment resulted from the sleep loss or from the stimulation per se. Accordingly, several older studies that showed severe impairment have been neglected or discounted, because the impairment could have resulted from the stimulation. To evaluate the effects of sleep deprivation independent of the stimulation used to enforce deprivation, we have used an apparatus that can awaken experimental rats while delivering the same gentle stimulation to control rats according to a schedule that only moderately shortens their sleep.

Author List

Rechtschaffen A, Bergmann BM, Everson CA, Kushida CA, Gilliland MA

Author

Carol A. Everson PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Arousal
Cerebral Cortex
Electroencephalography
Rats
Sleep Deprivation
Sleep Stages