Sleep deprivation in the rat: I. Conceptual issues. Sleep 1989 Feb;12(1):1-4
Date
02/01/1989Pubmed ID
2648532DOI
10.1093/sleep/12.1.1Scopus ID
2-s2.0-0024494517 (requires institutional sign-in at Scopus site) 37 CitationsAbstract
Sleep deprivation is a potentially powerful strategy for discovering the function(s) of sleep, but the approach has had limited success. Few studies have described serious physiological consequences of sleep deprivation, perhaps because the deprivation has not been maintained long enough. However, prolonging deprivation usually requires sustained, frequently intense stimulation, which makes it difficult to determine whether subsequent impairment resulted from the sleep loss or from the stimulation per se. Accordingly, several older studies that showed severe impairment have been neglected or discounted, because the impairment could have resulted from the stimulation. To evaluate the effects of sleep deprivation independent of the stimulation used to enforce deprivation, we have used an apparatus that can awaken experimental rats while delivering the same gentle stimulation to control rats according to a schedule that only moderately shortens their sleep.
Author List
Rechtschaffen A, Bergmann BM, Everson CA, Kushida CA, Gilliland MAAuthor
Carol A. Everson PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsArousal
Cerebral Cortex
Electroencephalography
Rats
Sleep Deprivation
Sleep Stages